NBEO General Physiology Exam 2025 – 400 Free Practice Questions to Pass the Exam

Intrinsic factor is a glycoprotein produced by the parietal cells in the stomach. Its primary role in digestion is to facilitate the absorption of vitamin B12, which is essential for various bodily functions, including red blood cell formation and neurological function. Vitamin B12, however, cannot be absorbed efficiently in the intestines without the presence of intrinsic factor.

When food is consumed, vitamin B12 binds to intrinsic factor in the stomach, and this complex then travels to the ileum, the final part of the small intestine, where B12 is absorbed through specific receptors. Without intrinsic factor, B12 absorption is significantly impaired, leading to potential deficiencies that can result in anemia and neurological issues.

Other choices, such as those related to carbohydrate absorption, gastric motility, or insulin sensitivity, do not pertain to the specific function of intrinsic factor, which is exclusively involved in the absorption of vitamin B12. Understanding the unique role of intrinsic factor emphasizes its importance in overall nutrient absorption and health.